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Appeal guide · Cancer

Cancer treatment denials

Oncology denials are often the most urgent — both medically and financially. Carriers sometimes deny first-line chemotherapy, immunotherapy, off-label uses, and proton therapy. Most reverse on appeal when the oncologist's documentation is filed correctly.

What gets denied

  • Off-label chemotherapy or immunotherapy
  • Proton beam therapy
  • CAR-T cell therapy
  • Genetic and biomarker testing
  • Second-opinion consultations at NCI centers
  • Compassionate-use drug coverage

Common denial reasons

  • Treatment deemed 'experimental' or 'investigational'
  • Off-label use not in NCCN compendium
  • Site of care (proton facility, NCI center) not in network
  • Genetic test not justified by family history

How we approach the appeal

Cite the NCCN, ASCO, and other oncology compendiums. Attach the oncologist's full pathology and staging report. Request expedited review on grounds of imminent risk to health. Many plans honor compassionate-use carve-outs once formally requested.

Filing window

Urgent: 72 hours. Standard: 30 days. Compassionate-use requests are often resolved in days.

Typical recovery

$10,000 – $500,000+

Documents we'll ask for
  • · Denial letter
  • · Oncologist's treatment plan
  • · Pathology and staging report
  • · Prior treatment summary
  • · Genetic / biomarker test results (if applicable)

Got a cancer denial?

Free 24-hour review. Send the denial letter and we'll tell you whether your case has a shot and what the next step would look like.

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This page provides general information about appeal strategy. It is not legal advice. Outcomes depend on documentation, plan terms, and timing.